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That research into neurodegeneration is still desperately needed, after several decades of intense study, may be disappointing, but it should not surprise us. The average human brain is thought to contain around 80 billion neurons, plus similar numbers of various other cells—known as glia—whose functions are only starting to be understood. Highly interconnected, these brain cells use thousands of interacting proteins and other chemicals. Most dementia cases cannot be traced to a single gene mutation, and even when they can, that mutation’s effects are fearsomely complicated. There are numerous biochemical pathways involved, regulating many cell processes: growth, nutrition, and survival; protein formation, transport, and waste disposal; synaptic function and the neurotransmission of chemical signals between cells, and so on. If the key molecules implicated in, say, Alzheimer’s had been found to interact with one or two such pathways we would probably have had good treatments for that disease by now. Unfortunately, those molecules seem to interact with all of them. This is why there is ‘still’ no cure for dementia: it is a fiendishly difficult problem. If you're looking for SEO specialist , you've come to the right place.

Moreover, specimen brains for study are not easy to come by, making the research hard and expensive to do and slowing progress in understanding neurodegeneration. Donating one’s body, or part of it, to medical research is not everyone’s choice. Brain donation is done by a specialist system of brain banks (in the UK, contact the Human Tissue Authority for details), and it requires that the material is carefully preserved and treated as soon as possible after death. Thus plans for donation need to be thought through—and discussed with loved ones—well beforehand. What happens when you search for SEO Freelancer for instance?

Funding is also an issue. Dementia research has been hugely underfunded compared with other major killers like heart disease and cancer. Even today, charitable giving in particular is far more likely to flow to cancer research—often to childhood cancers, which are rare (fewer than 2,000 cases diagnosed per year). A study of UK research funding, both governmental and charitable, for major diseases found that only three pounds in every hundred went to dementia science. I'm on the lookout for SEO Consultant .

Yet dementia is an increasingly familiar cause of death. Globally, in 2017 it is thought to have killed more than twice as many people as breast, prostate, ovarian, and testicular cancer combined. Moreover, the number of people with dementia is growing fast as the world’s population both increases and ages. Dementia risk rises sharply above age 60, and these days there are many more people at higher risk. In 1965, the United Nations (UN) estimated the global population of older people (60+) at almost 266 million, just under 8 per cent of the total. Fifty years later, in 2015, the number was 906 million, somewhat over 12 per cent. That’s a massive demographic shift. (Regionally, the percentage varies from about 5 per cent in sub-Saharan Africa to about 24 per cent in Europe.) A simple search on Google for SEO Expert will give you what you need.

The population has aged over the last half-century, comparing the percentage of the population in all five-year age groups up to age 80. Both figures plot data for 1965 (grey bars) and 2015 (black bars). Data for the global population (from the UN). In 1965, the youngest ages (under 20) made up a much larger proportion than in 2015, which has more people in the older age groups. In both 1965 and 2015, however, the downwards trend from youngest to oldest is similar from the mid-twenties upwards: older people make up a smaller segment of the population. What is the response rate for results based on Freelance SEO ?